DELINEATION OF PUTATIVE MECHANISMS INVOLVED IN ANTIBODY-MEDIATED CLEARANCE OF RABIES VIRUS FROM THE CENTRAL-NERVOUS-SYSTEM

被引：107

作者：

DIETZSCHOLD, B ^{[1
]}

KAO, M ^{[1
]}

ZHENG, YM ^{[1
]}

CHEN, ZY ^{[1
]}

MAUL, G ^{[1
]}

FU, ZF ^{[1
]}

RUPPRECHT, CE ^{[1
]}

KOPROWSKI, H ^{[1
]}

机构：

[1] WISTAR INST,PHILADELPHIA,PA 19109

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

VIRUS NEUTRALIZATION; TRANSCRIPTION;

D O I：

10.1073/pnas.89.15.7252

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus-neutralizing mAbs results in an endocytosis of the antibody, we hypothesize that an antibody may exert its inhibitory activity even after uptake by the cell. Post-exposure treatment of rats with a mAb that inhibited both virus spread and virus RNA transcription in vitro resulted in viral clearance from the central nervous system and protected the animals against a lethal rabies virus infection.

引用

页码：7252 / 7256

页数：5

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