Hemolytic Transfusion Reactions

被引:0
|
作者
Azik, Fatih Mehmet [1 ]
Bozkaya, Ikbal Ok [1 ]
Ozkasap, Serdar [2 ]
机构
[1] Ankara Cocuk Sagligi & Hastaliklari, Hematol Onkol Egitim Arastirma Hastanesi, Ankara, Turkey
[2] Rize Egitim Arastirma Hastanesi, Rize, Turkey
来源
关键词
Transfusion reaction; erythrocyte transfusion; hemolysis;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The prevalence of fatal hemolytic transfusion reactions (HTRs) is approximately 1: 200000 per unit. Acute HTRs occur during or within 24 h after administration of a blood product. Transfusion of incompatible red blood cells (RBCs), and, more rarely, of a large volume of incompatible plasma usually are the causative agents. Delayed HTRs are caused by a secondary immune response to an antigen on the donor's RBCs. Different mechanisms lead to intra-and extravascular hemolysis, such as complete complement activation, phagocytosis of RBCs covered with C3b by macrophages after incomplete complement activation, or destruction of RBCs covered only with IgG by direct cell to cell contact with K cells. The clinical consequences of HTRs are triggered via several pathophysiological pathways. Formation of anaphylatoxins, release of cytokines causing a systemic inflammatory response syndrome, activation of the kinin system, the intrinsic clotting cascade and fibrinolysis result in hypotension, disseminated intravascular coagulation, diffuse bleeding, and disruption of microcirculation leading to renal failure and shock. In this review, the symptoms of HTR are introduced, laboratory investigations and treatment are described, and some recommendations for prevention are given.
引用
收藏
页码:127 / 132
页数:6
相关论文
共 50 条
  • [1] Hemolytic Transfusion Reactions
    Strobel, Erwin
    [J]. TRANSFUSION MEDICINE AND HEMOTHERAPY, 2008, 35 (05) : 346 - 353
  • [2] HEMOLYTIC TRANSFUSION REACTIONS
    NICHOLSON, MJ
    [J]. ANESTHESIOLOGY, 1948, 9 (04) : 345 - 357
  • [3] HEMOLYTIC TRANSFUSION REACTIONS
    STUCKEY, MA
    THOMAS, JW
    OSOBA, D
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 1964, 90 (12) : 739 - &
  • [4] Hemolytic Transfusion Reactions
    Panch, Sandhya R.
    Montemayor-Garcia, Celina
    Klein, Harvey G.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (02): : 150 - 162
  • [5] Hemolytic Transfusion Reactions
    Sato, Tomohiko
    Goto, Naoko
    Tasaki, Tetsunori
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (14): : 1396 - 1397
  • [6] IMMUNE HEMOLYTIC TRANSFUSION REACTIONS AND PSEUDOHEMOLYTIC TRANSFUSION REACTIONS
    GILCHER, RO
    [J]. PLASMA THERAPY & TRANSFUSION TECHNOLOGY, 1985, 6 (01): : 7 - 17
  • [7] HEMOLYTIC AND PSEUDO-HEMOLYTIC TRANSFUSION REACTIONS - AN OVERVIEW OF THE HEMOLYTIC TRANSFUSION REACTIONS AND THE CLINICAL CONDITIONS THAT MIMIC THEM
    BEAUREGARD, P
    BLAJCHMAN, MA
    [J]. TRANSFUSION MEDICINE REVIEWS, 1994, 8 (03) : 184 - 199
  • [8] DELAYED HEMOLYTIC TRANSFUSION REACTIONS
    KURTIDES, ES
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1978, 240 (02): : 110 - 111
  • [9] Hemolytic Transfusion Reactions Reply
    Panch, Sandhya R.
    Montemayor-Garcia, Celina
    Klein, Harvey G.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (14): : 1397 - 1397
  • [10] DELAYED HEMOLYTIC TRANSFUSION REACTIONS
    STRAUSS, RA
    MORGAN, BB
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 245 (01): : 31 - 31