COEXISTENCE OF GLUCOCORTICOID RECEPTOR AND PHARMACOKINETIC ABNORMALITIES - FACTORS THAT CONTRIBUTE TO A POOR RESPONSE TO TREATMENT WITH GLUCOCORTICOIDS IN CHILDREN WITH ASTHMA

被引：21

作者：

KAMADA, AK

SPAHN, JD

SURS, W

BROWN, E

LEUNG, DYM

SZEFLER, SJ

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT, DIV CLIN PHARMACOL, DENVER, CO 80206 USA

[2] NATL JEWISH CTR IMMUNOL & RESP MED, DEPT MED, DIV CLIN PHARMACOL, DENVER, CO 80206 USA

[3] NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT, DIV ALLERGY CLIN IMMUNOL, DENVER, CO 80206 USA

[4] NATL JEWISH CTR IMMUNOL & RESP MED, DEPT MED, DIV ALLERGY CLIN IMMUNOL, DENVER, CO 80206 USA

[5] UNIV COLORADO, HLTH SCI CTR, DEPT PEDIAT, DENVER, CO 80262 USA

[6] UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL, DENVER, CO 80262 USA

来源：

JOURNAL OF PEDIATRICS | 1994年 / 124卷 / 06期

关键词：

D O I：

10.1016/S0022-3476(05)83198-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Rapid glucocorticoid clearance and abnormal glucocorticoid receptor binding have been described as factors that contribute to an inadequate response to treatment with glucocorticoids in patients with asthma. We report the coexistence of these abnormalities in children with severe asthma who respond poorly to systemic glucocorticoid therapy.

引用

页码：984 / 986

页数：3

共 11 条

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[3] Expression kinetics of Glucocorticoid Receptor lsoforms Predicts Treatment Response to Glucocorticoids in Uveitis patients
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[4] Reduced dexamethasone uptake by lymphoblasts and weakened glucocorticoid receptor (GR) reaction cascade is associated with a poor response to glucocorticoids in treatment of acute lymphoblastic leukemia (ALL).
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[6] Glucocorticoid Receptor-β Is Downregulated by Vitamin D Treatment in Children with Low Vitamin D Levels but Not in Allergic Asthma
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Sancak, Recep
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Bedir, Abdulkerim
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[7] Loss of glucocorticoid receptor expression in diagnostic biopsies of metastatic prostate cancer is associated with poor response to sequential docetaxel treatment
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Arthritis Research & Therapy, 24
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