EXPRESSION OF PSEUDOMONAS-AERUGINOSA VIRULENCE GENES REQUIRES CELL-TO-CELL COMMUNICATION

被引：677

作者：

PASSADOR, L ^{[1
]}

COOK, JM ^{[1
]}

GAMBELLO, MJ ^{[1
]}

RUST, L ^{[1
]}

IGLEWSKI, BH ^{[1
]}

机构：

[1] UNIV ROCHESTER, SCH MED & DENT, DEPT MICROBIOL & IMMUNOL, ROCHESTER, NY 14620 USA

来源：

SCIENCE | 1993年 / 260卷 / 5111期

关键词：

D O I：

10.1126/science.8493556

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pseudomonas aeruginosa is an opportunistic human pathogen that causes a variety of infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of elastase, one of the virulence factors produced by this organism, requires the transcriptional activator LasR. Experiments with gene fusions show that gene lasI is essential for high expression of elastase. The lasI gene is involved in the synthesis of a diffusible molecule termed Pseudomonas autoinducer (PAI). PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.

引用

页码：1127 / 1130

页数：4

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