AGE-RELATED-CHANGES IN THE MOLECULAR-PROPERTIES OF VITREOUS COLLAGEN

被引：17
|
作者：
AKIBA, J
UENO, N
CHAKRABARTI, B
机构：
[1] HARVARD UNIV,SCH MED,SCHEPENS EYE RES INST,DEPT OPHTHALMOL,20 STANIFORD ST,BOSTON,MA 02114
[2] ASAHIKAWA MED COLL,DEPT OPHTHALMOL,ASAHIKAWA 07811,JAPAN
来源：
CURRENT EYE RESEARCH | 1993年 / 12卷 / 10期
关键词：
D O I：
10.3109/02713689309020402
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
To understand the molecular events underlying rheological vitreous changes, age-related changes in the molecular properties of bovine and human vitreous collagen were monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The adult bovine vitreous showed an increase in the highmolecular-weight components of the collagen compared with the young samples. In addition, the apparent molecular size of the alpha-chain of the adult type II collagen was slightly larger than that of the young samples. The same tendency also was observed in human vitreous. The increase of high-molecular-weight components of the vitreous collagen could be attributed to intermolecular cross-links of the peptide chains.
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页码：951 / 954
页数：4
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