Inflammatory myofibroblastic tumour: a rare entity with wide differential diagnosis

被引：0
|
作者：
Gilani, S. M. [1 ]
Kowalski, P. J. [1 ]
机构：
[1] St John Hosp & Med Ctr, Dept Pathol, Detroit, MI 48236 USA
来源：
PATHOLOGICA | 2014年 / 106卷 / 01期
关键词：
Myofibroblastic tumour; Anaplastic lymphoma kinase; Surgical resection; Follow-up;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Inflammatory myofibroblastic tumour (IMT) is a rare, distinctive mesenchymal neoplasm. Grossly, it appears as a circumscribed mass with a rubbery to firm cut surface. Microscopically, it is characterized by a spindle cell proliferation within a myxoid stroma with admixed plasma cells, lymphocytes and eosinophils. Immunohistochemical staining is usually positive for vimentin, smooth muscle actin (SMA) and anaplastic lymphoma kinase (ALK). ALK gene rearrangement is present in approximately 50-70% IMTs. The standard treatment is surgical resection, and it is essential to differentiate IMT from benign and malignant mimickers so that appropriate therapy may be provided. Clinical and radiological follow-up is required to detect recurrence.
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页码：1 / 6
页数：6
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