PURITY EVALUATION OF 6-ALPHA-METHYLPREDNISOLONE ACETATE BY HPLC

被引：4
|
作者：
SIGNORETTI, EC
VALVO, L
SAVELLA, AL
CAVINA, G
机构：
[1] Istituto Superiore di Sanità, 00161 Roma
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 07期
关键词：
6-ALPHA-METHYLPREDNISOLONE ACETATE; REVERSED-PHASE CHROMATOGRAPHY; PURITY EVALUATION; FOREIGN SUBSTANCES;
D O I：
10.1016/0731-7085(93)80009-P
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A high-performance liquid chromatographic method is described for the analysis and identification of related impurities in pharmaceutical-grade 6alpha-methylprednisolone acetate (MPA). Eight MPA impurities derived from synthesis and/or degradation processes were identified. The method is compared to other analytical procedures recently proposed for the European Pharmacopoeia.
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页码：587 / 593
页数：7
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