COOPERATION OF GROEL/GROES AND DNAK/DNAJ HEAT-SHOCK PROTEINS IN PREVENTING PROTEIN MISFOLDING IN ESCHERICHIA-COLI

被引：196

作者：

GRAGEROV, A ^{[1
]}

NUDLER, E ^{[1
]}

KOMISSAROVA, N ^{[1
]}

GAITANARIS, GA ^{[1
]}

GOTTESMAN, ME ^{[1
]}

NIKIFOROV, V ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,INST CANC RES,NEW YORK,NY 10032

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 21期

关键词：

PROTEIN AGGREGATION; PROTEIN FOLDING; CHAPERONES; RPOH MUTANTS;

D O I：

10.1073/pnas.89.21.10341

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Newly synthesized proteins aggregate extensively in Escherichia coli rpoH mutants, which are deficient in the heat shock proteins (hsp). Overproduction of either GroEL and GroES or DnaK and DnaJ prevents aggregation. If expressed together, the four hsp are effective at physiological concentrations. Our data suggest that the GroEL and GroES proteins and the DnaK and Dnaj proteins have complementary functions in the folding and assembly of most proteins.

引用

页码：10341 / 10344

页数：4

共 50 条

[1] DNAK AND DNAJ HEAT-SHOCK PROTEINS PARTICIPATE IN PROTEIN EXPORT IN ESCHERICHIA-COLI
WILD, J
ALTMAN, E
YURA, T
GROSS, CA
GENES & DEVELOPMENT, 1992, 6 (07) : 1165 - 1172
[2] AUTOREGULATION OF THE ESCHERICHIA-COLI HEAT-SHOCK RESPONSE BY THE DNAK AND DNAJ HEAT-SHOCK PROTEINS
LIBEREK, K
GEORGOPOULOS, C
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 11019 - 11023
[3] The role of DnaK/DnaJ and GroEL/GroES systems in the removal of endogenous proteins aggregated by heat-shock from Escherichia coli cells
Kedzierska, S
Staniszewska, M
Wegrzyn, A
Taylor, A
FEBS LETTERS, 1999, 446 (2-3) : 331 - 337
[4] HEAT-SHOCK PROTEINS DNAK AND GROEL FACILITATE EXPORT OF LACZ HYBRID PROTEINS IN ESCHERICHIA-COLI
PHILLIPS, GJ
SILHAVY, TJ
NATURE, 1990, 344 (6269) : 882 - 884
[5] EFFECTS OF MUTATIONS IN HEAT-SHOCK GENES GROES AND GROEL ON PROTEIN EXPORT IN ESCHERICHIA-COLI
KUSUKAWA, N
YURA, T
UEGUCHI, C
AKIYAMA, Y
ITO, K
EMBO JOURNAL, 1989, 8 (11): : 3517 - 3521
[6] ESCHERICHIA-COLI DNAJ AND GRPE HEAT-SHOCK PROTEINS JOINTLY STIMULATE ATPASE ACTIVITY OF DNAK
LIBEREK, K
MARSZALEK, J
ANG, D
GEORGOPOULOS, C
ZYLICZ, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) : 2874 - 2878
[7] INVITRO ROLES OF ESCHERICHIA-COLI DNAJ AND DNAK HEAT-SHOCK PROTEINS IN THE REPLICATION OF ORIC PLASMIDS
MALKI, A
HUGHES, P
KOHIYAMA, M
MOLECULAR & GENERAL GENETICS, 1991, 225 (03): : 420 - 426
[8] THE ESCHERICHIA-COLI HEAT-SHOCK PROTEINS GROEL AND GROES MODULATE THE FOLDING OF THE BETA-LACTAMASE PRECURSOR
LAMINET, AA
ZIEGELHOFFER, T
GEORGOPOULOS, C
PLUCKTHUN, A
EMBO JOURNAL, 1990, 9 (07): : 2315 - 2319
[9] A HUMAN HOMOLOG OF THE ESCHERICHIA-COLI DNAJ HEAT-SHOCK PROTEIN
RAABE, T
MANLEY, JL
NUCLEIC ACIDS RESEARCH, 1991, 19 (23) : 6645 - 6645
[10] THE DNAK PROTEIN MODULATES THE HEAT-SHOCK RESPONSE OF ESCHERICHIA-COLI
TILLY, K
MCKITTRICK, N
ZYLICZ, M
GEORGOPOULOS, C
CELL, 1983, 34 (02) : 641 - 646

← 1 2 3 4 5 →