ALFENTANIL INFUSION IN TOTAL INTRAVENOUS ANESTHESIA (TIVA) - POPULATION PHARMACOKINETICS FAILS TO PREDICT PLASMA-CONCENTRATION OF ALFENTANIL

被引：4
|
作者：
JENSTRUP, M [1 ]
FRUERGARD, K [1 ]
NIELSEN, J [1 ]
MOLLER, AM [1 ]
WIBERGJORGENSEN, F [1 ]
机构：
[1] CENT HOSP HILLEROD,DEPT ANAESTHESIOL,HILLEROD,DENMARK
来源：
ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1992年 / 36卷 / 08期
关键词：
ANALGESICS; ALFENTANIL; HYPNOTICS; PROPOFOL; PHARMACOKINETICS; TOTAL INTRAVENOUS ANESTHESIA;
D O I：
10.1111/j.1399-6576.1992.tb03576.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
In order to evaluate the ability to predict plasma concentrations from population-corrected pharmacokinetics, a prospective study comprising 14 women admitted for elective hysterectomy was done. Alfentanil was given in combination with propofol in a total intravenous anaesthesia technique. The predicted median alfentanil concentration (289(256-363) ng ml-1) was significantly lower than the measured median plasma concentration of 368(168-666) ng ml-1). In conclusion, population-based pharmacokinetics were found not to be accurate as they underestimate plasma concentrations of alfentanil.
引用
收藏
页码：846 / 847
页数：2
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