PHARMACOLOGICAL MODULATION OF THE ANTIOXIDANT ENZYMES ACTIVITIES AND THE CONCENTRATION OF PEROXIDATION PRODUCTS IN FIBROBLASTS STIMULATED WITH ELASTIN PEPTIDES

被引：9
|
作者：
GMINSKI, J
WEGLARZ, L
DROZDZ, M
GOSS, M
机构：
[1] Department of Biochemistry and Chemistry, Silesian Medical Academy, 18 Medyków St, PL-40752
来源：
GENERAL PHARMACOLOGY | 1991年 / 22卷 / 03期
关键词：
D O I：
10.1016/0306-3623(91)90012-U
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Elastin peptides (kappa-elastin) prepared by alcoholic potassium hydroxide degradation of insoluble elastin were shown to increase the activities of antioxidant enzymes (SOD, CAT, GSH-Px) and the lipid peroxide concentration within fibroblasts. 2. The preincubation of cells with nifedipine (calcium channel antagonist) and trifluoperazine (calmodulin antagonist) caused the decrease in the activities of studied enzymes and the concentration of TBA-reactive products in fibroblasts stimulated with kappa-elastin. 3. The preincubation with ketotifen (antiallergic drug) has no effect on the activities of SOD, CAT, GSH-Px and the lipid peroxide concentration in stimulated cells. 4. These data suggest the possibilities of pharmacological modulation of the biological effects induced by elastin-derived peptides.
引用
收藏
页码：495 / 497
页数：3
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