STRUCTURE AND POLYMORPHISM OF THE MOUSE MYELIN/OLIGODENDROCYTE GLYCOPROTEIN GENE

被引：27
|
作者：
DAUBAS, P [1 ]
PHAMDINH, D [1 ]
DAUTIGNY, A [1 ]
机构：
[1] UNIV PARIS 07, INST NEUROSCI,MOLEC NEUROGENET LAB,CNRS,URA 1488, F-75252 PARIS 05, FRANCE
来源：
GENOMICS | 1994年 / 23卷 / 01期
关键词：
D O I：
10.1006/geno.1994.1456
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have isolated and characterized genomic clones containing the mouse myelin/oligodendrocyte glycoprotein (MOG) gene. It spans a region of 12.5 kb and consists of eight exons. Its exon-intron structure differs from that of classical MHC-class I genes, with which it is linked in the mouse genome. Nucleotide sequencing of the 5' flanking region reveals that it contains several putative protein-binding sites, some of them in common with other myelin gene promoters. One intragenic polymorphism has been identified: it consists of a GA repeat, defining at least three alleles in mouse inbred strains, and is easily detectable using the polymerase chain reaction method. (C) 1994 Academic Press, Inc.
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页码：36 / 41
页数：6
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