Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology

被引:19
|
作者
Satou, Kazuhito [1 ]
Shimoji, Makiko [1 ]
Tamotsu, Hinako [1 ]
Juan, Ayaka [1 ]
Ashimine, Noriko [1 ]
Shinzato, Misuzu [1 ]
Toma, Claudia [2 ]
Nohara, Toshitsugu [2 ]
Shiroma, Akino [1 ]
Nakano, Kazuma [1 ]
Teruya, Kuniko [1 ]
Terabayashi, Yasunobu [1 ]
Ohki, Shun [1 ]
Koizumi, Nobuo [3 ]
Okano, Shou [4 ]
Suzuki, Toshihiko [2 ]
Hirano, Takashi [1 ]
机构
[1] Okinawa Inst Adv Sci, Uruma, Okinawa, Japan
[2] Univ Ryukyus, Dept Mol Bacteriol & Immunol, Grad Sch Med, Nishihara, Okinawa, Japan
[3] Natl Inst Infect Dis, Dept Bacteriol 1, Shinjuku Ku, Tokyo, Japan
[4] Okinawa Prefectural Inst Hlth & Environm, Dept Biol Sci, Nanjo, Okinawa, Japan
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D O I
10.1128/genomeA.00882-15
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摘要
Here, we report the complete genome sequences of low-passage virulent and high-passage avirulent variants of pathogenic Leptospira interrogans serovar Manilae strain UP-MMC-NIID, a major causative agent of leptospirosis. While there were no major differences between the genome sequences, the levels of base modifications were higher in the avirulent variant.
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