EFFECTS OF A NOVEL MELATONIN ANALOG ON CIRCADIAN-RHYTHMS OF BODY-TEMPERATURE AND ACTIVITY IN YOUNG, MIDDLE-AGED, AND OLD RATS

被引：33
|
作者：
KOSTERVANHOFFEN, GC
MIRMIRAN, M
BOS, NPA
WITTING, W
DELAGRANGE, P
GUARDIOLALEMAITRE, B
机构：
[1] NETHERLANDS INST BRAIN RES, 1105 AZ AMSTERDAM, NETHERLANDS
[2] INST RECH INT SERVIER, F-92415 COURBEVOIE, FRANCE
来源：
NEUROBIOLOGY OF AGING | 1993年 / 14卷 / 06期
关键词：
CIRCADIAN RHYTHMS; BODY TEMPERATURE; ACTIVITY; SLEEP; AGING; MELATONIN; SUPRACHIASMATIC NUCLEUS; PINEAL GLAND;
D O I：
10.1016/0197-4580(93)90040-I
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Circadian rhythms of body temperature and activity were recorded in young, middle-aged, and old rats. A new melatonin analog, S20242, was administered daily around the onset of darkness for a 2-week period. Compared to the young animals, there was a significant age-related reduction in the amplitude and stability of body temperature and activity in both the middle-aged and old rats. In these two groups there was an improvement of the circadian rhythm of body temperature as a result of daily application of the melatonin analog.
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页码：565 / 569
页数：5
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