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ANTIALLERGIC EFFECT OF BRYONOLIC ACID FROM LUFFA-CYLINDRICA CELL-SUSPENSION CULTURES

被引：39
|
作者：
TANAKA, S
UNO, C
AKIMOTO, M
TABATA, M
HONDA, C
KAMISAKO, W
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,KYOTO 606,JAPAN
[2] MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,NISHINOMIYA,HYOGO 663,JAPAN
来源：
PLANTA MEDICA | 1991年 / 57卷 / 06期
关键词：
ANTIALLERGIC ACTIVITY; BRYONOLIC ACID; 3-BETA-HYDROXY-D-C-FRIEDOOLEAN-8-EN-29-OIC ACID; GLYCYRRHETINIC ACID; LUFFA-CYLINDRICA; CELL SUSPENSION CULTURE;
D O I：
10.1055/s-2006-960199
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The anti-allergic activity of bryonolic acid (1) isolated from the cultured cells of Luffa cylindrica L. (Cucurbitaceae) was compared with that of glycyrrhetinic acid (2), the aglycone of gylcyrrhizin from licorice. Compound 1, when administered to rats intraperitoneally at a dose of 600 mg/kg, inhibited homologous passive cutaneous anaphylaxis more strongly than 2 at the same dose. Compound 1 also significantly inhibited delayed hypersensitivity in mice which could not be inhibited by 2. In contrast to 2, 1 showed not only little toxicity but no visible side effects on mice, without impairing the activity of the hepatic enzyme (4,5-beta-dihydrocortisone:NADP+ DELTA(4)-oxidoreductase) involved in steroid catabolism.
引用
收藏
页码：527 / 530
页数：4
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