EXPRESSION OF NUCLEAR RETINOIC ACID RECEPTORS IN RAT ADIPOSE-TISSUE

被引：30
|
作者：
RIAZULHAQ
CHYTIL, F
机构：
[1] Department of Biochemistry Vanderbilt University School of Medicine Nashville
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期
关键词：
D O I：
10.1016/0006-291X(91)90462-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of nuclear retinoic acid receptors (RAR-α, β and γ) was examined by Northern blots in rat lung, liver, and adipose tissue. Three transcripts of approximate sizes 7.3, 3.7, and 2.8 Kb were detected in adipose tissue. In contrast to adipose tissue only 3.7 and 2.8 Kb mRNA species were detected in liver and lung. Two RAR-β gene transcripts (3.3 and 3.0 Kb) were expressed in adipose tissue, liver, and lung. RAR-γ mRNA (3.36 Kb) was detected in adipose tissue and lung. The distribution of three RARs in adipose tissue suggests the physiological role of retinoic acid in the regulation of specific genes via RARs in adipocytes. © 1991.
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页码：1539 / 1544
页数：6
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