Clopidogrel is an oral anti-platelet drug used in patients with myocardial infarction for prevention of thrombotic events. In the present study, we report here a case of a 55-year-old woman who developed a spontaneous anterior abdominal wall haematoma following three months of clopidogrel treatment. The patient developed pain abdomen and swelling in the lower abdominal wall and ecchymotic patch was observed on the lower abdomen. There was a palpable mass in the lower quadrant of the abdomen in midline and on right side. Abdominal ultrasonography revealed a hypoechoic mass in the region of swelling in the anterior abdominal wall. Computed Tomography (CT) of abdomen showed non-enhancing hyperdense mass in the lower abdomen in anterior abdominal wall suggestive of haematoma. The haematoma was evacuated completely. Radiologists should be aware of spontaneous haematomas due to clopidogrel while interpreting ultrasonography and CT images.