IMMUNOREACTIVE CORTICOTROPIN-RELEASING HORMONE LEVELS IN DISCRETE HYPOTHALAMIC NUCLEI OF GENETICALLY-OBESE ZUCKER RATS

被引：10
|
作者：
NAKAISHI, S
NAKAI, Y
FUKATA, J
NAITO, Y
USUI, T
FUKUSHIMA, M
JINGAMI, H
NAKAO, K
IMURA, H
机构：
[1] KYOTO UNIV, COLL MED TECHNOL,DIV SCI NURSING,53 KAWAHARA CHO, SHOGOIN,SAKYO KU, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, DEPT INTERNAL MED, KYOTO 606, JAPAN
[3] KYOTO UNIV, SCH MED, DEPT ANESTHESIOL, KYOTO 606, JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 159卷 / 1-2期
关键词：
ZUCKER RAT; CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; MEDIAN EMINENCE; OBESITY;
D O I：
10.1016/0304-3940(93)90790-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The levels of immunoreactive corticotropin-releasing hormone (ir-CRH) were measured in discrete hypothalamic nuclei and the median eminence of obese Zucker rats and their lean littermates. More than 90% of total hypothalamic ir-CRH was detected in the median eminence in both obese and lean rats. Though ir-CRH levels in the paraventricular nucleus of obese rats tended to be lower than those of their lean littermates, no significant difference of ir-CRH levels was observed in any hypothalamic nuclei studied between obese and lean rats. However, ir-CRH levels in the median eminence of obese rats were significantly lower than those of their lean littermates (5263 +/- 438 pg/tissue vs. 7050 +/- 473 pg/tissue, P < 0.05). These results suggest that the hypoactive hypothalamic CRH tonus would play some role in the phenotypic expression of obesity in the genetically obese Zucker rats.
引用
收藏
页码：29 / 31
页数：3
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