The evaluation of perinatal outcomes in pregnancies complicated with thrombophilias

Objective: In our study we included pregnant patients diagnosed with thrombophilia in whom thromboprophylaxis was initiated and evaluated their perinatal outcomes (pregnancy loss, preeclampsia, low birth weight, preterm labor, and venous thrombosis). We aimed to compare perinatal outcomes of the study group with those of control group with negative thrombophilia screening results. Material and Methods: Pregnant subjects that applied to Obstetrics and Gynecology Department of eukurova University Faculty of Medicine Hospital between June 2010 and February 2012 were recruited in the study. Patients with a positive thrombophilia screening for primary and secondary recurrent pregnancy loss were initiated a thromboprophylaxia protocol in the first trimester and their demographic backgrounds and past obstetric histories were also recorded. In addition to this, the type of thrombophilia and number of thrombophilia defects were also noted and the route of birth and perinatal outcomes were evaluated prospectively. The control group included patients who had a history of recurrent unexplained miscarriages, with a negative thrombophilia screening. Differences between both groups were statistically significant at a p value <0.05. Results: Sixty patients diagnosed with thrombophilia were included in the study group, while 50 patients with no etiological cause including thrombophilia composed the control group. When the perinatal outcomes were compared; pregnancy loss, development of preeclampsia/eclampsia (p=0.257), rate of low weight baby according to gestational week (p=0.619), preterm birth rate (p=0.232) and the incidence of venous thrombosis (p=0.246) did not differ significantly. The cesarean section rate in the study group was 55% (33-60) and 18% (9/50) in the study group (p=0.000) and the difference was statistically significant between both groups. Conclusion: Our study discovered similar findings and perinatal outcomes in patients with and without thrombophilia. The only significant difference between both groups was the difference in cesarean rates.