A COMPARATIVE-STUDY OF ATYPICAL AND MELANOCYTIC NEVI ON THE TROPICAL ISLAND CURACAO AND IN THE NETHERLANDS

A cross-sectional study was undertaken in 270 inhabitants of The Netherlands (moderate maritime climate, latitude 51 degrees 5' N-53 degrees 3' N) with skin types I-III and 757 inhabitants of the tropical island Curacao (latitude 12 degrees 2' N-12 degrees 23' N). The latter group consisted of 282 White individuals (mostly Dutch immigrants) and 475 people with non-White skin types IV, V and VI. All participants underwent total skin examination and melanocytic naevi (MN) and clinically atypical naevi (AN) were noted, There was no statistical difference in the mean number of naevi greater than or equal to 2 mm or greater than or equal to 5 mm between the Curacao and The Netherlands White groups, but the mean number of naevi greater than or equal to 2 mm and greater than or equal to 5 mm was significantly lower in the Curacao non-White group, We found no obvious differences in mean naevus counts between genders and the various comparable age groups, Furthermore, we found no significant difference in mean crude and mean age-standardized prevalence of (one or more) AN between Whites in The Netherlands and on Curacao. The Mantel-Haenszel prevalence ratio weighted for age and gender differences of Curacao Whites vs non-Whites was 5.93 (95% confidence interval 3.9-12.0), demonstrating that AN are significantly less prevalent in darker skin types, In all groups, people with AN had significantly more MN than people without AN. We found a generation-dependent difference in the expression of AN among White inhabitants of The Netherlands and on Curacao, with a higher prevalence of AN in the younger generation.