BIOCOMPATIBLE PARTICLES BASED ON BLOCK-COPOLYMER AGGREGATES FOR INTRAVASCULAR ADMINISTRATION

被引：2
|
作者：
PETRAK, K
机构：
[1] CIBA-GEIGY Pharmaceuticals, Basic Pharmaceutic Research, Ardsley, NY 10502-2699
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1993年 / 8卷 / 02期
关键词：
D O I：
10.1177/088391159300800206
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The aggregation between hydrophobic/hydrophilic block copolymer unimers in water was analyzed. Based on the molecular weight and composition of the block polymer, the number of unimers in each particulate aggregate, the size of the particle and the size of the particle core, the average distance between the solvated chains attached to the micelle core was calculated. The distance between the terminally attached chains was compared with the Flory radius R(f) which was related to the extent that the chains were forced to stay in the ''brush'' conformation. By selecting the proper structure of block copolymer, micelles composed of water-soluble polymer chains were prepared with a ''near ideal'' saturated surface.
引用
收藏
页码：178 / 187
页数：10
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