INVIVO SELECTION FOR TRANSMISSIBLE DRUG-RESISTANCE IN SALMONELLA-TYPHI DURING ANTIMICROBIAL THERAPY

被引：33
|
作者：
SCHWALBE, RS
HOGE, CW
MORRIS, JG
OHANLON, PN
CRAWFORD, RA
GILLIGAN, PH
机构：
[1] VET ADM MED CTR,LAB SERV,ALBANY,NY 10965
[2] UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21201
[3] UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201
[4] N CAROLINA MEM HOSP,CLIN MICROBIOL IMMUNOL LABS,CHAPEL HILL,NC 27514
[5] UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27514
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 01期
关键词：
D O I：
10.1128/AAC.34.1.161
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.
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页码：161 / 163
页数：3
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