FLUORINATED PHOSPHOLIPID-BASED VESICLES AS POTENTIAL-DRUG CARRIERS - ENCAPSULATION/SUSTAINING OF DRUGS AND STABILITY IN HUMAN SERUM

被引：3

作者：

FREZARD, F

SANTAELLA, C

VIERLING, P

RIESS, JG

机构：

[1] Unité de Chimie Moléculaire, Associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 1994年 / 22卷 / 04期

关键词：

D O I：

10.3109/10731199409138844

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The release of entrapped 5(6)-carboxyfluorescein from fluorinated vesicles in a buffer or in human serum is considerably less than that from hydrogenated liposomes. The presence of a fluorinated core inside the liposomal membrane definitely reduces its permeability. In some cases, the stability of liposomes made from fluorinated phospholipids alone is better than that of egg phosphatidylcholine cholesterol 1/1 vesicles, which are among the least permeable and most stable hydrogenated liposomes.

引用

页码：1403 / 1408

页数：6

共 3 条

[1] PERMEABILITY AND STABILITY IN BUFFER AND IN HUMAN SERUM OF FLUORINATED PHOSPHOLIPID-BASED LIPOSOMES
FREZARD, F
SANTAELLA, C
VIERLING, P
RIESS, JG
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1192 (01): : 61 - 70
[2] Improved stability of highly fluorinated phospholipid-based vesicles in the presence of bile salts
Gadras, C
Santaella, C
Vierling, P
[J]. JOURNAL OF CONTROLLED RELEASE, 1999, 57 (01) : 29 - 34
[3] FLUORINATED PHOSPHATIDYLCHOLINE-BASED LIPOSOMES - H+/NA+ PERMEABILITY, ACTIVE DOXORUBICIN ENCAPSULATION AND STABILITY IN HUMAN SERUM
FREZARD, F
SANTAELLA, C
MONTISCI, MJ
VIERLING, P
RIESS, JG
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1194 (01): : 61 - 68

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