SEARCH FOR A GENE PREDISPOSING TO MANIC-DEPRESSION ON CHROMOSOME-21

Six kindreds containing multiple cases of Manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21, The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree [Straub et al., 1993: The American Society of Human Genetics]. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance, The nonparametric affected sib pair test did not yield significant evidence of linkage. (C) 1995 Wiley-Liss, Inc.