SEROTONIN INDUCES PROGESTERONE RELEASE FROM HUMAN GRANULOSA-CELLS IN A SUPERFUSED GRANULOSA-CELL SYSTEM

被引：16
|
作者：
BODIS, J [1 ]
TOROK, A [1 ]
TINNEBERG, HR [1 ]
HANF, V [1 ]
PAPENFUSS, F [1 ]
SCHWARZ, H [1 ]
机构：
[1] UNIV TUBINGEN,FRAUENKLIN,SCHLEICHSTR 4,D-72076 TUBINGEN,GERMANY
来源：
ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 1993年 / 253卷 / 02期
关键词：
GRANULOSA CELL-SUPERFUSION SYSTEM; SEROTONIN; MIANSERIN; PROPRANOLOL;
D O I：
10.1007/BF02768730
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The dynamics of the release of progesterone (P) by human granulosa cells (GCs) was investigated in a granulosa cell-superfusion system using serotonin (5-HT), propanolol (PR), or mianserin (MI). Granulosa cells were obtained from 8 women undergoing in-vitro fertilization and embryo transfer. Progesterone was measured using radioimmunoassay. Serotonin (100 pMol) induced P release from human GCs. This effect was specifically blocked by 100 pMol MI whilst 100 pMol PR was ineffective in this condition. The results suggest. that the superfused GC system is suitable for studying the dynamics of steroid secretion by human GCs.
引用
收藏
页码：59 / 64
页数：6
相关论文
共 50 条
  • [1] INFLUENCE OF SEROTONIN ON PROGESTERONE AND ESTRADIOL SECRETION OF CULTURED HUMAN GRANULOSA-CELLS
    BODIS, J
    TOROK, A
    TINNEBERG, HR
    HANF, V
    HAMORI, M
    CLEDON, P
    [J]. FERTILITY AND STERILITY, 1992, 57 (05) : 1008 - 1011
  • [2] The effect of catecholamines, acetylcholine and histamine on progesterone release by human granulosa cells in a granulosa cell superfusion system
    Bódis, J
    Koppán, M
    Kornya, L
    Tinneberg, HR
    Török, A
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2002, 16 (04) : 259 - 264
  • [3] Influence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system
    Bódis, J
    Koppán, M
    Kornya, L
    Tinneberg, HR
    Török, A
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2001, 52 (03) : 198 - 202
  • [4] PROLACTIN INDUCTION OR INHIBITION OF STEROIDOGENESIS IN CULTURED PORCINE GRANULOSA-CELLS - INFLUENCE OF GRANULOSA-CELL MATURATION
    VELDHUIS, JD
    KLASE, PA
    HAMMOND, JM
    [J]. BIOLOGY OF REPRODUCTION, 1979, 20 : A70 - A70
  • [5] ESTRADIOL AND PROGESTERONE PRODUCTION IN HUMAN GRANULOSA-CELLS FROM PERIOVULATORY FOLLICLES
    ROMERO, C
    MIRANDA, C
    HESS, R
    [J]. ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES, 1988, 21 (02): : R346 - R346
  • [6] PROGESTERONE AS AN AUTOCRINE PARACRINE REGULATOR OF HUMAN GRANULOSA-CELL PROLIFERATION
    CHAFFKIN, LM
    LUCIANO, AA
    PELUSO, JJ
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (06): : 1404 - 1408
  • [7] PROGESTERONE-RECEPTOR IN GRANULOSA-CELL TUMOR
    MEYER, JS
    RAO, BR
    VALDES, R
    BURSTEIN, R
    WASSERMAN, HC
    [J]. GYNECOLOGIC ONCOLOGY, 1982, 13 (02) : 252 - 257
  • [8] MELATONIN DIRECTLY STIMULATES THE SECRETION OF PROGESTERONE BY HUMAN GRANULOSA-CELLS
    WEBLEY, GE
    LUCK, MR
    [J]. ACTA ENDOCRINOLOGICA, 1985, 108 : 91 - 92
  • [9] PROGESTERONE PRODUCTION BY AN OVARIAN GRANULOSA-CELL CARCINOMA
    LOMAX, CW
    MAY, HV
    PANKO, WB
    THORNTON, WN
    [J]. OBSTETRICS AND GYNECOLOGY, 1977, 50 (01): : S39 - S40
  • [10] GRANULOSA-CELL TUMOURS INDUCED IN MICE BY PROGESTERONE
    LIPSCHUTZ, A
    IGLESIAS, R
    PANASEVICH, VI
    SALINAS, S
    [J]. BRITISH JOURNAL OF CANCER, 1967, 21 (01) : 144 - +
12345