IMMUNOGLOBULIN HEAVY-CHAIN ALLOTYPES IN A SAMPLE OF SICILIAN PATIENTS WITH CELIAC-DISEASE

被引：0
|
作者：
CARUSO, C [1 ]
CANDORE, G [1 ]
MODICA, MA [1 ]
LIO, D [1 ]
MARINO, V [1 ]
MALTESE, I [1 ]
CATALDO, F [1 ]
ALBEGGIANI, A [1 ]
机构：
[1] UNIV PALERMO,PEDIAT CLIN R,I-90134 PALERMO,ITALY
来源：
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS | 1991年 / 8卷 / 01期
关键词：
CELIAC DISEASE; IMMUNOGLOBULIN ALLOTYPES; HLA; IMMUNOREGULATION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The authors have studied the immunoglobulin heavy chain allotypes in 14 Sicilian patients with celiac disease (CD) and in 75 healthy controls. No association has been found between CD and Gm or Km phenotypes. When the role of Gm phenotypes in immune response against gliadin was analyzed, fb-positive CD patients on gluten-free diet for 1 year showed an increased antigliadin IgG response. Comparing the values of fb-positive subjects with those of negative ones, a significant difference was observed. These data, demonstrating that the presence or absence of a phenotype is able to define the breadth of immune response against alpha-gliadin antigen, are indicative of the role played by Ig allotypes in CD.
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页码：1 / 5
页数：5
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