THE DISTRIBUTION OF OMEGA-CONOTOXIN MVIIC(NLE)-BINDING SITES IN RAT-BRAIN MEASURED BY AUTORADIOGRAPHY

被引：18
|
作者：
FILLOUX, F
KARRAS, J
IMPERIAL, JS
GRAY, WR
OLIVERA, BM
机构：
[1] UNIV UTAH,DEPT PEDIAT,SALT LAKE CITY,UT 84132
[2] UNIV UTAH,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132
[3] UNIV UTAH,DEPT BIOL,SALT LAKE CITY,UT 84132
来源：
NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期
关键词：
OMEGA-CONOTOXIN; OMEGA-CONOTOXIN MVIIC; CALCIUM CHANNEL; NEURONAL CHANNEL; SYNAPSE; NEUROTRANSMITTER RELEASE; CEREBELLUM;
D O I：
10.1016/0304-3940(94)90774-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An analogue of omega-conotoxin MVIIC, [I-125]omega-MVIIC(n/e) has been employed in an autoradiographic assay to define the distribution of binding sites in rat brain of this neuronal calcium channel antagonist. In comparison with N-type channels (labeled by [I-125]omega-conotoxin GVIA), omega-MVIIC(n/e) sites are much denser in cerebellum (molecular layer) than in forebrain. Binding in thalamus is also comparatively high for omega-MVIIC(n/e). Under these conditions, [(125I)]omega-MVIIC(n/e) binding to rat brain sections is not displaceable by the N-channel antagonist, omega-conotoxin GVIA. The calcium channel blocker I-125]omega-conotoxin MVIIC(n/e) labels a unique set of binding sites in mammalian brain.
引用
收藏
页码：263 / 266
页数：4
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