EFFECT OF ISOBUTYL ESTER OF RETINOIC ACID ON THE CELLULAR COMPOSITION OF BRONCHOALVEOLAR LAVAGE AND ON THE MITOTIC-ACTIVITY OF ALVEOLAR MONOCYTE-MACROPHAGES IN RATS

被引:0
|
作者
POKROVSKAYA, MS [1 ]
ROMANOVA, LK [1 ]
MLADKOVSKAYA, TB [1 ]
KULIKOVA, GV [1 ]
机构
[1] RUSSIAN ACAD MED SCI,HUMAN MORPHOL RES INST,PULMONOL LAB,MOSCOW 109801,RUSSIA
关键词
ALVEOLAR MACROPHAGES; MITOTIC ACTIVITY; RETINOIDS; BRONCHOALVEOLAR LAVAGE;
D O I
10.1007/BF02445745
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Different doses of the isobutyl ester of retinoic acid were administered intraperitoneally into rats for two weeks. The dose of 1 mg/kg caused a significant increase in the mitotic activity of cells of the macrophagal series in alveoli; an anti-inflammatory effect was observed at a dose of 10 mg/kg. The isobutyl ester of retinoic acid did not affect the cell ratio (alveolar macrophages, lymphocytes, neutrophils, eosinophils) in the internal medium of the lungs.
引用
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页码:1337 / 1339
页数:3
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