INHIBITION BY LACTOFERRIN AND KAPPA-CASEIN GLYCOMACROPEPTIDE OF BINDING OF CHOLERA-TOXIN TO ITS RECEPTOR

被引：98

作者：

KAWASAKI, Y ^{[1
]}

ISODA, H ^{[1
]}

TANIMOTO, M ^{[1
]}

DOSAKO, S ^{[1
]}

IDOTA, T ^{[1
]}

AHIKO, K ^{[1
]}

机构：

[1] SNOW BRAND MILK PROD CO LTD, SAPPORO RES LAB, SAPPORO 065, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1992年 / 56卷 / 02期

关键词：

D O I：

10.1271/bbb.56.195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibition from binding of Cholera toxin (CT) to Chinese hamster ovary (CHO)-K1 cells and ganglioside G(M1) by lactoferrin (Lf) and kappa-casein glycomacropeptide (GMP) from cow's milk was examined. Both Lf and GMP effectively reduced the CT-derived morphological changes in CHO-K1 cells. The competitive binding assay demonstrated that both Lf and GMP inhibited the binding of CT to G(M1), although their affinity for CT was lower than that of G(M1). The inhibitory effect of Lf and GMP seemed to be attributed to their terminal sialic acid, although the sugar chain sequence only partially fitted to the CT-receptor.

引用

页码：195 / 198

页数：4

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