OF REACTIVE ANTI-INFLAMMATORY CYTOKINES IN ACUTE AND CHRONIC PANCREATITIS

Development of recommendations choice of effective tactics of surgical interventions in acute pancreatitis (AP) is still relevant in surgery. Existing theories of pathogenesis of inflammation in the pancreas highlight the key role of cytokines in the formation of pancreatic necrosis. The role of anti-inflammatory cytokines transforming growth factor-beta 1 (TGF-beta 1) in the development of the severity and nature of the inflammatory changes in AP has not been studied. According to current data TGF-beta 1 affects the processes of cooperation of inflammatory cells in the pancreas, fibroblast proliferation and synthesis of extracellular matrix components. The features of the content of the transforming growth factor beta 1 (TGF-beta 1) in the serum of 74 patients with acute and chronic pancreatitis-21 in the first 10 days of hospitalization. Proven diagnostic significance level of TGF-beta 1i dynamics indicator in the nature and degree of inflammation in the pancreas. Defined diagnostic thresholds TGF-beta 1 and sensitivity of anti-inflammatory cytokine in acute and chronic pancreatitis.