EFFECTS OF CHLOROQUINE ON PENTYLENETETRAZOL-INDUCED CONVULSIONS IN MICE

被引：11
|
作者：
NGOUEMO, P
BENATTIA, M
BELAIDI, M
机构：
[1] UNIV MONTPELLIER 1,INST BIOL,CNRS,UPR 9008,INSERM U249,EXPTL MED LAB,F-34090 MONTPELLIER,FRANCE
[2] UNIV MONTPELLIER 2,INSERM,U336,MONTPELLIER,FRANCE
来源：
PHARMACOLOGICAL RESEARCH | 1994年 / 30卷 / 02期
关键词：
CHLOROQUINE; CONVULSIONS; PENTYLENETETRAZOL; MICE;
D O I：
10.1016/1043-6618(94)80001-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of chloroquine pretreatment were investigated on pentylenetetrazol-induced clonic-tonic convulsions in mice. The results demonstrated that lower doses of chloroquine (1.0-5.0 mg kg(-1)) significantly induced a delay in onset time to the clonic component of convulsions and reduced the incidence of the tonic phase of convulsions and mortality. In contrast, at a higher dose range (10.0-50.0 mg kg(-1)) chloroquine had opposite effects. This study points out the biphasic action of chloroquine on clonic-tonic PTZ convulsions and its preferential effect against the tonic phase of convulsions.
引用
收藏
页码：99 / 103
页数：5
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