ROLE OF HERBAL FORMULATION OF GARLIC ON LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES RELATED DYSLIPIDEMIA

Objective: To evaluate the role and side effects of garlic on lipid profile in diabetic dyslipidemic patients along with their lipid lowering efficacy. Methodology: This cross sectional study was carried out at Surgeon Munawar Memorial Hospital Bahadurabad Karachi. The study period consisted of 8 weeks st st from 1 February 2015 to 31 March 2015. Patients with age between 30 and 60 years of either gender with diabetic dyslipidemia were included. The exclusion criteria included pregnant/lactating females, liver, renal and established coronary artery disease or ischemic heart disease. Results: Total of 30 diabetic dyslipidemic patients with abnormal lipid profile were included. Patients were orally administered with local herbal product of garlic (300 mg/day) for 8 weeks. Serum levels of cholesterol, high density lipoprotein (HDL), triglyceride (TG), and low density lipoprotein (LDL) were estimated in patients before and after treatment with local herbal product of garlic (300 mg/day). After the treatment of garlic, serum cholesterol and low density lipoprotein were significantly decreased but there was no effect on triglyceride levels (p > 0.05). Conclusion: On the basis of this study we concluded that herbal products like garlic significantly decreases cholesterol, low density lipoprotein (LDL) and increases high density lipoprotein (HDL).