PHARMACOKINETIC AND IMMUNOPHARMACOLOGICAL ASPECTS OF THE INTERACTION OF PRODIGIOZAN WITH PSYCHOTROPIC-DRUGS

In experiments on white male mice it was found that an immunostimulant prodigiozan suppresses the activity of cytochrome P-450-dependent liver monohygenases that results in modulation of the activity of neuroleptics (aminazine and haloperidol) administered against its background. Their activity is assessed by the "open field "test" and the "tail suspension test". One could observe a delay of the occurrence of the neuroleptics' effect and prolongation of the effect. Acute toxicity of aminazine was shown to decrease. The changes are most probably due to a slowing of metabolism of the neuroleptics in the liver. On the other hand, administration of neuroleptics against the background of prodigiozan fails to affect its immunostimulating effect despite diverse influences of the drugs on the activity of the liver monooxygenase.