ENDOTHELIN-INDUCED CONSTRICTION OF GUINEA-PIG AIRWAYS - ROLE OF PLATELET-ACTIVATING FACTOR

被引：32
|
作者：
BATTISTINI, B [1 ]
SIROIS, P [1 ]
BRAQUET, P [1 ]
FILEP, JG [1 ]
机构：
[1] UNIV SHERBROOKE,FAC MED,DEPT PHARMACOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
(Guinea-pig); BN; 52021; Bronchi (upper); Endothelin; PAF (platelet-activating factor; PAF-acether); Trachea;
D O I：
10.1016/0014-2999(90)90449-G
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Endothelin-1 (ET-1, 1-100 nM) evoked a concentration-dependent contraction of guinea pig trachea and upper bronchi in vitro. The response was significantly attenuated by BN 52021 (ginkgolide B, 10 μM), a specific receptor antagonist to platelet-activating factor. Precontraction of the tissues with endothelin (50 nM) desensitized tissues to platelet-activating factor (200 nM), while preincubation of the tissues with platelet-activating factor slightly inhibited the response to endothelin. These findings suggest that platelet-activating factor may mediate endothelin-induced airway contraction in the guinea pig. © 1990.
引用
收藏
页码：307 / 310
页数：4
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