FORMULATION AND INVITRO EVALUATION OF GALANTAMINE PATCHES FOR TRANSDERMAL DRUG DELIVERY SYSTEM

In present study transdermal drug delivery of Galantamine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches were developed by using polymers Eudragit-L100, HPMCk(4)M and HPMCk15M.Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Formulations were prepared by taking Eudragit-L100, HPMCk(4)M, HPMCk15M as polymers in the concentrations of 100 mg,150 mg and 200 mg from F1-F9 formulations, Eudragit-L100 100mg and HPMCk(4)M 100mg in F10, Eudragit-L100 100mg and HPMCk15M 100mg in F11, HPMCk(4)M 100mg and HPMCk15M 100mg in F12, all the formulations were evaluated for various physical parameters, invitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.5% drug release in 12 hours. For F6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that they were no interactions.