RELAXATION DYNAMICS OF MYOGLOBIN IN SOLUTION

被引：125
|
作者：
TIAN, WD
SAGE, JT
SRAJER, V
CHAMPION, PM
机构：
[1] Department of Physics, Northeastern University, Boston
来源：
PHYSICAL REVIEW LETTERS | 1992年 / 68卷 / 03期
关键词：
D O I：
10.1103/PhysRevLett.68.408
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The geminate rebinding kinetics of MbCO in solution at high temperature (260-300 K) shows nonexponential behavior (stretched, beta approximately 1/2) that may be related to nonequilibrium relaxation of the distal pocket. A two-pulse photolysis experiment, which probes a kinetically selected subpopulation, demonstrates that the nonexponential behavior arises from a fluctuationally averaged system and also reveals slow interconversion times for large-scale protein motions. Measurements as a function of temperature lead to a direct determination of the Arrhenius barrier at the heme (18 +/- 2 kJ/mole).
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页码：408 / 411
页数：4
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