Liposomal doxorubicin-induced cardiotoxicity - case report

We report on a case of a female patient with relapsed metastatic bone disease from triple-negative breast cancer after primary radical treatment. In years 2002-2010 patient has received four lines of chemotherapy. After receiving 6th course of full-dose liposomal doxorubicin during fourth-line treatment patient has been diagnosed with acute cardiac failure with decreased left ventricular ejection fraction to value of 35%. Another ECHO examination after 2 months showed no significant improvement despite the applied treatment (LVEF 38%). Chemotherapy has been discontinued. Patient has died 4 months later because of cachexia and disease progression. Presented case illustrates the difficulties associated with increasing risk of complications among patients treated with several lines of chemotherapy.