MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL RAT ACTIVIN RECEPTOR

被引：33

作者：

LEGERSKI, R ^{[1
]}

ZHOU, X ^{[1
]}

DRESBACK, J ^{[1
]}

EBERSPAECHER, H ^{[1
]}

MCKINNEY, S ^{[1
]}

SEGARINI, P ^{[1
]}

DECROMBRUGGHE, B ^{[1
]}

机构：

[1] CELTRIX PHARMACEUT,PALO ALTO,CA 94303

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90535-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the isolation of a full-length rat cDNA for a new activin receptor. The deduced amino acid sequence of this receptor shows 67 percent overall identity with that of a previously identified mouse activin receptor. As predicted for the mouse activin receptor, the amino acid sequence of the rat receptor is consistent with a polypeptide containing an extracellular ligand binding domain, a hydrophobic transmembrane domain, and a serine/threonine kinase intracellular domain. In an expression assay, this new receptor was found to bind I125 radiolabeled activin. © 1992.

引用

页码：672 / 679

页数：8

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