CLINICAL-SIGNIFICANCE OF ANTINUCLEAR ANTIBODIES IN JAPANESE PATIENTS WITH SYSTEMIC-SCLEROSIS

被引：18
|
作者：
IGARASHI, A [1 ]
TAKEHARA, K [1 ]
SOMA, Y [1 ]
KIKUCHI, K [1 ]
ISHIBASHI, Y [1 ]
机构：
[1] UNIV TOKYO, BRANCH HOSP,FAC MED,DEPT DERMATOL, 3-28-6 MEJIRODAI,BUNKYO, TOKYO 113, JAPAN
来源：
DERMATOLOGICA | 1990年 / 180卷 / 03期
关键词：
anti-nRNP antibody; anti-Scl-70; antibody; anticentromere antibody; antinuclear antibodies; systemic sclerosis;
D O I：
10.1159/000248013
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Clinical significance of specific antinuclear antibodies (ANA) in Japanese patients with systemic sclerosis was studied. The patients with systemic sclerosis were classified into four groups according to ANA: (1) anticentromere antibody-positive; (2) anti-Scl-70-antibody-positive; (3) anti-nRNP antibody-positive, and (4) others. The mean score (the number of positive signs in six selected specific signs) of the patients with anti-Scl-70 antibody was significantly higher than those of the other three groups. More frequent contracture of phalanges in the patients with anti-Scl-70 antibody, less diffuse pigmentation in the patients with anti-nRNP antibody, and less pulmonary fibrosis in the patients with anticentromere antibody were revealed. As shown above, the detection of specific ANA in systemic sclerosis is clinically important.
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收藏
页码：136 / 140
页数：5
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