ADHESION OF RHEUMATOID PERIPHERAL-BLOOD AND SYNOVIAL-FLUID MONONUCLEAR-CELLS TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA

被引:6
|
作者
KADIOGLU, A [1 ]
SHELDON, P [1 ]
机构
[1] UNIV LEICESTER, DEPT MICROBIOL, POB 138, MED SCI BLDG, LEICESTER LE1 9HN, ENGLAND
关键词
D O I
10.1136/ard.51.1.126
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mononuclear cells isolated from paired blood and synovial fluid of seven patients with rheumatoid arthritis showed cytoadherence to porcine Peyer's patch high endothelial venules using the Stamper-Woodruff method. A significantly greater proportion of binding was found among the synovial fluid lymphocytes. These would appear to be a population of cells that share adherence characteristics with cells known to be of gut mucosal origin, suggesting that in rheumatoid arthritis some lymphocytes derived from mucosa migrate to joints.
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页码:126 / 127
页数:2
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