THE GLYCINE-SITE NMDA RECEPTOR ANTAGONIST, R-(+)-CIS-BETA-METHYL-3-AMINO-1-HYDROXYPYRROLID-2-ONE, L-687,414 IS ANTICONVULSANT IN BABOONS

被引：37
|
作者：
SMITH, SE [1 ]
MELDRUM, BS [1 ]
机构：
[1] INST PSYCHIAT,DEPT NEUROL,DE CRESPIGNY PK,DENMARK HILL,LONDON SE5 8AF,ENGLAND
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 01期
关键词：
GLYCINE; L-687,414; NMDA (N-METHYL-D-ASPARTATE); BEHAVIOR; EXCITATORY AMINO ACIDS; EPILEPSY;
D O I：
10.1016/0014-2999(92)90270-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The glycine-site NMDA receptor antagonist, R-(+)cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one (L-687,414) administered i.t. to photosensitive baboons. The anticonvulsant action of L-687,414 (5-45 mg kg-1) was dose-dependent and peaked between 15 min and 2 h after administration. Gross behavioural effects were not observed at the doses tested. L-687,414 is a potent systemically acting anticonvulsant apparently devoid of serious side effects.
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收藏
页码：109 / 111
页数：3
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