THE IMP DEHYDROGENASE INHIBITOR MYCOPHENOLIC-ACID ANTAGONIZES THE CTP SYNTHETASE INHIBITOR 3-DEAZAURIDINE IN MOLT-3 HUMAN LEUKEMIA-CELLS - A CENTRAL ROLE FOR PHOSPHORIBOSYL PYROPHOSPHATE

被引：2

作者：

VANBERG, AA

MOOYER, PAW

VANLENTHE, H

STET, EH

DEABREU, RA

VANKUILENBURG, ABP

VANGENNIP, AH

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT PEDIAT,1100 DE AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN CHEM,1100 DE AMSTERDAM,NETHERLANDS

[3] UNIV NIJMEGEN,CTR CANC,NIJMEGEN,NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1995年 / 50卷 / 07期

关键词：

MYCOPHENOLIC ACID; 3-DEAZAURIDINE; IMP DEHYDROGENASE; CTP SYNTHETASE; PHOSPHORYBOSYL-PYROPHOSPHATE; ANTAGONISM;

D O I：

10.1016/0006-2952(95)00228-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazauridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazauridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway.

引用

页码：1095 / 1098

页数：4