DEGRADATION AND DISPOSAL OF SOME ENZYME-INHIBITORS

被引：3
|
作者：
LUNN, G
SANSONE, EB
机构：
[1] Program Resources, Inc./DynCorp, Environmental Control and Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, 21702-1201, MD, PO Box B
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 1994年 / 48卷 / 02期
关键词：
SAFETY; DEGRADATION; STABILITY; ENZYME INHIBITORS; PMSF; APMSF; AEBSF; TLCK; TPCK; HPLC;
D O I：
10.1007/BF02796162
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, Nor-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability of these compounds decreased as the pH increased.
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页码：57 / 59
页数：3
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