TYPE-1 AND TYPE-2 ANGIOTENSIN-II RECEPTORS IN FETAL-RAT BRAIN

被引：0
|
作者：
TSUTSUMI, K [1 ]
VISWANATHAN, M [1 ]
STROMBERG, C [1 ]
SAAVEDRA, JM [1 ]
机构：
[1] NIMH,CLIN SCI LAB,PHARMACOL SECT,9000 ROCKVILLE PIKE,BLDG 10,ROOM 2D045,BETHESDA,MD 20892
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 198卷 / 01期
关键词：
BRAIN DEVELOPMENT; ANGIOTENSIN II RECEPTOR SUBTYPES; RENIN-ANGIOTENSIN SYSTEM; NUCLEUS-TRACTUS-SOLITARII (NTS); CHOROID PLEXUS; INFERIOR OLIVE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Brain angiotensin II receptors were located in 18-day-old rat embryos by quantitative autoradiography. In the nucleus of the solitary tract and choroid plexus, binding was displaced by the type-1 antagonist DuP 753. In the inferior olive, paratrigeminal and hypoglossal nuclei, binding was displaced by the type-2 antagonist CGP 42112 A. Meninges and cephalic soft tissues contained predominantly type-2 angiotensin II receptors. Our results indicate a role for type-1 and type-2 angiotensin II receptors during brain development.
引用
收藏
页码：89 / 92
页数：4
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