CONNECTIN, AN ELASTIC PROTEIN OF STRIATED-MUSCLE

Connectin, also called titin, a giant elastic protein of striated muscle (approximate to 3000 kDa) mainly consists of fibronectin type III and immunoglobulin C2 globular domains, the beta-sheets of which are parallel to the main axis of the molecule. One connectin molecule runs through the I band and binds onto the myosin filament up to the M line starting from the Z line. It positions the myosin filament at the center of a sarcomere. Connectin is also responsible for resting tension generation. Biodiversity of the connectin family exists in invertebrate muscle.