ON THE MECHANISM OF TOPOISOMERASE-I INHIBITION BY CAMPTOTHECIN - EVIDENCE FOR BINDING TO AN ENZYME DNA COMPLEX

被引:524
|
作者
HERTZBERG, RP
CARANFA, MJ
HECHT, SM
机构
关键词
D O I
10.1021/bi00437a018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:4629 / 4638
页数:10
相关论文
共 50 条
  • [1] INHIBITION OF TOPOISOMERASE-I BY ANTHRACYCLINE ANTIBIOTICS - EVIDENCE FOR GENERAL INHIBITION OF TOPOISOMERASE-I BY DNA-BINDING AGENTS
    CROW, RT
    CROTHERS, DM
    JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (19) : 3191 - 3194
  • [2] MECHANISM OF INHIBITION OF MAMMALIAN DNA TOPOISOMERASE-I BY HEPARIN
    ISHII, K
    FUTAKI, S
    UCHIYAMA, H
    NAGASAWA, K
    ANDOH, T
    BIOCHEMICAL JOURNAL, 1987, 241 (01) : 111 - 119
  • [3] ENHANCEMENT OF CAMPTOTHECIN FLUORESCENCE UPON TOPOISOMERASE-I BINDING
    LIROVCHIK, LV
    ALEXANDROVA, ES
    GABIBOV, AG
    BRONSTEIN, IB
    DOKLADY AKADEMII NAUK, 1995, 340 (02) : 271 - 272
  • [4] STRUCTURAL MODIFICATIONS OF CAMPTOTHECIN AND EFFECTS ON TOPOISOMERASE-I INHIBITION
    CROW, RT
    CROTHERS, DM
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) : 4160 - 4164
  • [5] INTRACELLULAR EFFECTS OF CAMPTOTHECIN ARE CONSISTENT WITH TOPOISOMERASE-I INHIBITION
    MATTERN, MR
    MONG, SM
    BARTUS, HF
    JOHNSON, RK
    MIRABELLI, CK
    CROOKE, ST
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1986, 27 : 280 - 280
  • [6] EVIDENCE THAT DNA TOPOISOMERASE-I IS NECESSARY FOR THE CYTO-TOXIC EFFECTS OF CAMPTOTHECIN
    ENG, WK
    FAUCETTE, L
    JOHNSON, RK
    STERNGLANZ, R
    MOLECULAR PHARMACOLOGY, 1988, 34 (06) : 755 - 760
  • [7] RIGID ANALOGS OF CAMPTOTHECIN AS DNA TOPOISOMERASE-I INHIBITORS
    LACKEY, K
    BESTERMAN, JM
    FLETCHER, W
    LEITNER, P
    MORTON, B
    STERNBACH, DD
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (06) : 906 - 911
  • [8] SEQUENCE SPECIFICITY OF DNA TOPOISOMERASE-I IN THE PRESENCE AND ABSENCE OF CAMPTOTHECIN
    THOMSEN, B
    MOLLERUP, S
    BONVEN, BJ
    FRANK, R
    BLOCKER, H
    NIELSEN, OF
    WESTERGAARD, O
    EMBO JOURNAL, 1987, 6 (06): : 1817 - 1823
  • [9] MECHANISMS OF CAMPTOTHECIN RESISTANCE IN YEAST DNA TOPOISOMERASE-I MUTANTS
    KNAB, AM
    FERTALA, J
    BJORNSTI, MA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (30) : 22322 - 22330
  • [10] THE BASIS FOR CAMPTOTHECIN ENHANCEMENT OF DNA BREAKAGE BY EUKARYOTIC TOPOISOMERASE-I
    PORTER, SE
    CHAMPOUX, JJ
    NUCLEIC ACIDS RESEARCH, 1989, 17 (21) : 8521 - 8532