INTERLEUKIN-4 INDUCES CD4+ CD8- TO CD8+ CD4- TRANSFORMATION OF HUMAN NEONATAL T-CELLS BY WAY OF A DOUBLE POSITIVE INTERMEDIATE

被引：2
|
作者：
REASON, DC
EBISAWA, M
SAITO, H
NAGAKURA, T
IIKURA, Y
机构：
[1] Division of Allergy, National Children's Medical Research Center, Setagaya-ku, Tokyo, 154
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)92396-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have determined that IL-4 induces the generation of CD4+ CD8+ T cells in cultures of neonatal lymphocytes. Sorting, positive, and negative selection experiments indicate that these cells arise from a subpopulation of CD4+ CD8- cells present in the neonate but not in the adult. We have further determined that these IL-4 generated "double positive" cells further differentiate to express only the CD8 marker. Our findings suggest an undescribed and dramatic role for IL-4 in T cell differentiation. © 1990.
引用
收藏
页码：830 / 836
页数：7
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