SOLID-PHASE SYNTHESIS OF HEAD-TO-TAIL CYCLIC-PEPTIDES VIA LYSINE SIDE-CHAIN ANCHORING

被引：70
|
作者：
ALSINA, J [1 ]
RABANAL, F [1 ]
GIRALT, E [1 ]
ALBERICIO, F [1 ]
机构：
[1] UNIV BARCELONA,DEPT ORGAN CHEM,E-08028 BARCELONA,SPAIN
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 51期
关键词：
ACTIVE CARBONATE RESINS; ALLYL ESTERS; N; N'-DISUCCINIMIDYL CARBONATE; LYSINE CYCLIC PEPTIDES; ORTHOGONAL PROTECTION; SOLID-PHASE SYNTHESIS;
D O I：
10.1016/0040-4039(94)88531-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The N,N'-disuccinimidyl carbonate (DSC) has been successfully used for the efficient conversion of conventional hydroxymethyl resins into active carbonate resins, which are suitable for the incorporation of protected amino acids via an amino function, allowing the preparation of ''head-to-tail'' cyclic lysine containing peptides.
引用
收藏
页码：9633 / 9636
页数：4
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