NEPHROPATHY PROTECTION AGAINST MERCURIC-CHLORIDE BY SODIUM SELENITE IN THE RAT

被引：0
|
作者：
BRAUN, JP
SENER, S
RICO, A
BENARD, P
BURGATSACAZE, V
机构：
来源：
COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D | 1979年 / 288卷 / 11期
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D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Daily i.p. injection of 2.5 or 5 .mu.mol HgCl2 to male rats weighing 250-350 g induces an early massive increase of urine .gamma.-glutamyl transferase [GGT] activity. Under the same conditions, equimolecular administration of sodium selenite and mercuric chloride induces no enzymuria increase for the low dose; for the high dose, a minor and more persistent increase of urine GGT is observed. The activity of urine GGT in vivo establishes that sodium selenite protects rat kidney against the toxic effects of mercuric chloride.
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页码：959 / 962
页数：4
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