INFLUENCE OF ALPHA-THALASSEMIA ON THE RETINOPATHY OF HOMOZYGOUS SICKLE-CELL DISEASE

被引：11
|
作者：
FOX, PD
HIGGS, DR
SERJEANT, GR
机构：
[1] UNIV W INDIES,MRC LABS,KINGSTON 7,JAMAICA
[2] JOHN RADCLIFFE HOSP,INST MOLEC MED,MOLEC HAEMATOL UNIT,MRC,OXFORD OX3 9DU,ENGLAND
来源：
BRITISH JOURNAL OF OPHTHALMOLOGY | 1993年 / 77卷 / 02期
关键词：
D O I：
10.1136/bjo.77.2.89
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Homozygous alpha+ thalassaemia (alpha-/alpha-) ameliorates some of the clinical manifestations of homozygous sickle cell (SS) disease but its effect on retinal complications remains unknown. This has been assessed by visual examination and fluorescein angiography in 39 subjects with SS disease and homozygous alpha+ thalassaemia and in 39 age/sex matched controls with SS disease but with a normal alpha globin genotype (alphaalpha/alphaalpha). The results indicate that homozygous alpha+ thalassaemia reduces the extent of peripheral retinal vessel closure but has no apparent effect on the frequency of proliferative sickle retinopathy.
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页码：89 / 90
页数：2
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