BACTERIAL-RESISTANCE MECHANISMS AS THERAPEUTIC TARGETS

被引:38
|
作者
COLEMAN, K [1 ]
ATHALYE, M [1 ]
CLANCEY, A [1 ]
DAVISON, M [1 ]
PAYNE, DJ [1 ]
PERRY, CR [1 ]
CHOPRA, I [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,MICROBIOL RES,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
关键词
D O I
10.1093/jac/33.6.1091
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In the 50 years since antimicrobial agents were first introduced, bacteria have acquired a wide variety of mechanisms which have enabled them to resist the effects of these drugs. One way of overcoming this problem is to administer an antibiotic with an agent which counteracts the mechanism of resistance to that antibiotic; an example of such an approach which has already been successfully implemented is the combination of a β-lactam antibiotic with a β-Mactamase inhibitor. This review describes antibiotic resistance mechanisms which might lend themselves to an inhibitor approach and the potential therapeutic applications of such a strategy. © 1994 The British Society for Antimicrobial Chemotherapy.
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页码:1091 / 1116
页数:26
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